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3-Chloro-6-(2,2,6,6-tetramethylpiperidin-4-yloxy)pyridazine

  • CAS No. 1562338-69-5

  • Cat. No. CS-0017893
  • Molecule weight269.77
  • Purity≥97%
  • MDL No.MFCD30532981

*For research and further manufacturing use only, not for direct human use.

3-Chloro-6-(2,2,6,6-tetramethylpiperidin-4-yloxy)pyridazine|CS-0017893

Structure of 1562338-69-5

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General Information

  • CAS No. 1562338-69-5
  • Cat. No. CS-0017893
  • Purity ≥97%
  • MDL No. MFCD30532981
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₀ClN₃O
  • Molecular Weight 269.77
  • Synonym(s) 3-chloro-6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazine
  • SMILES ClC1=NN=C(OC2CC(C)(C)NC(C)(C)C2)C=C1

Description

This pyridazine derivative features a chlorinated heterocyclic core paired with a sterically hindered tetramethylpiperidin-4-yloxy substituent, enhancing solubility and stability. The electron-deficient pyridazine ring enables selective coupling reactions in synthetic intermediates, while the bulky piperidine moiety reduces unwanted side reactivity. Designed for use in advanced medicinal chemistry and materials synthesis, it offers improved handling under standard conditions.

Application

3-Chloro-6-(2,2,6,6-tetramethylpiperidin-4-yloxy)pyridazine serves as a versatile building block in medicinal chemistry, enabling the construction of pyridazinyl-containing scaffolds through palladium-catalyzed cross-coupling reactions. The chloropyridazine core exhibits high reactivity in Suzuki, Stille, and Buchwald–Hartwig transformations, while the sterically hindered tetramethylpiperidine group enhances solubility and metabolic stability. This compound offers excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   47.04
  • LogP   2.818
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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