6-Chloro-1-methylindolin-2-one

Name: 6-Chloro-1-methylindolin-2-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 156136-55-9
Cat. No. CS-0514066
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-1-methylindolin-2-one|CS-0514066

Structure of 156136-55-9

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Description

6-Chloro-1-methylindolin-2-one features a chlorinated indolinone core with enhanced electronic properties from the electron-withdrawing chlorine at the 6-position. This bench-stable scaffold integrates readily into medicinal chemistry libraries, offering improved metabolic stability and solubility in polar solvents. The methyl group at nitrogen enhances lipophilicity and target engagement potential.

Application

6-Chloro-1-methylindolin-2-one serves as a versatile scaffold for medicinal chemistry and process development, enabling efficient access to substituted indolines via palladium-catalyzed cross-coupling. The chloro group at the 6-position facilitates direct functionalization, while the lactam carbonyl and methyl substituent provide favorable polarity and metabolic stability. Its bench-stable crystalline form simplifies handling and purification in multi-step syntheses.

General Information

CAS No. 156136-55-9
Cat. No. CS-0514066
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₈ClNO
Molecular Weight 181.62
Synonym(s) 6-chloro-1-methyl-2,3-dihydro-1H-indol-2-one
SMILES O=C1N(C)C2=C(C=CC(Cl)=C2)C1

Computational Chemistry Data

TPSA 20.31
LogP 1.8589
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Key Words

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6-Chloro-1-methylindolin-2-one

CAS No. 156136-55-9

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