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Structure of 155957-47-4
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4-Chloro-6-(2,2,2-trifluoroethoxy)pyrimidine is a fluorinated heterocyclic building block featuring a chlorine substituent at C4 and a trifluoroethoxy group at C6. This combination imparts enhanced metabolic stability and lipophilicity, enabling efficient incorporation into bioactive molecules for medicinal chemistry applications. The molecule exhibits bench-stable handling characteristics and compatibility with diverse synthetic transformations.
4-Chloro-6-(2,2,2-trifluoroethoxy)pyrimidine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based scaffolds through palladium-catalyzed cross-coupling reactions. The chloro group facilitates Suzuki, Stille, and Buchwald–Hartwig couplings, while the trifluoroethoxy substituent enhances metabolic stability and modulates lipophilicity. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501
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Lot numbers can be found on the outside label of a product: