Boc-L-cyclobutylglycine

Name: Boc-L-cyclobutylglycine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 155905-77-4
Cat. No. CS-W021157
Purity≥97%
MDL No.MFCD06659975

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HazMat Fee

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 155905-77-4

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Description

Boc-L-cyclobutylglycine features a cyclobutyl ring fused to a glycine backbone, delivering enhanced conformational rigidity for peptide backbone stabilization. This sterically constrained scaffold improves metabolic stability and modulates bioavailability in peptidomimetic design. The Boc protecting group enables straightforward incorporation into solid-phase synthesis workflows under standard conditions.

Application

Boc-L-cyclobutylglycine serves as a valuable building block in peptide synthesis, offering a rigid cyclobutyl side chain that modulates conformational flexibility and enhances metabolic stability. Its Boc group provides reliable protection for the amine functionality, enabling straightforward deprotection under mild acidic conditions. The compound exhibits excellent bench stability, facilitates efficient purification, and demonstrates broad compatibility in standard coupling protocols, making it well-suited for the construction of bioactive peptides and cyclic scaffolds.

General Information

CAS No. 155905-77-4
Cat. No. CS-W021157
Purity ≥97%
MDL No. MFCD06659975
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₉NO₄
Molecular Weight 229.27
Synonym(s) None
SMILES O=C(O)[C@@H](NC(OC(C)(C)C)=O)C1CCC1

Computational Chemistry Data

TPSA 75.63
LogP 1.7644
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Glycine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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Boc-L-cyclobutylglycine

CAS No. 155905-77-4

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