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CS-W001157 4
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6-Chloro-1-methyl-1H-pyrazolo[4,3-c]pyridine

  • CAS No. 1558302-68-3

  • Cat. No. CS-0036837
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Chloro-1-methyl-1H-pyrazolo[4,3-c]pyridine|CS-0036837

Structure of 1558302-68-3

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Description

6-Chloro-1-methyl-1H-pyrazolo[4,3-c]pyridine features a chlorinated pyrazolopyridine core with enhanced electron-deficient character, enabling efficient coupling in cross-coupling reactions. The methyl group at the 1-position improves solubility and stability under standard conditions, while the chlorine serves as a reactive handle for palladium-catalyzed transformations. This scaffold integrates readily into complex heterocyclic architectures.

Application

6-Chloro-1-methyl-1H-pyrazolo[4,3-c]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to substituted pyrazolopyridines via palladium-catalyzed cross-coupling reactions. Its chlorine atom facilitates nucleophilic substitution under mild conditions, while the methyl group enhances solubility and metabolic stability. The scaffold exhibits excellent bench stability and compatibility with standard reaction workflows, making it ideal for rapid library synthesis and API development.

General Information

  • CAS No. 1558302-68-3
  • Cat. No. CS-0036837
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClN₃
  • Molecular Weight 167.60
  • Synonym(s) 6-chloro-1-methyl-pyrazolo[4,3-c]pyridine
  • SMILES CN1C2=C(C=NC(=C2)Cl)C=N1

Computational Chemistry Data

  • TPSA   30.71
  • LogP   1.6217
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group :
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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