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CS-W001157 4
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6-Chloro-1-methyl-1H-pyrazolo[4,3-c]pyridine

  • CAS No. 1558302-68-3

  • Cat. No. CS-0036837
  • Molecule weight167.60
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloro-1-methyl-1H-pyrazolo[4,3-c]pyridine|CS-0036837

Structure of 1558302-68-3

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General Information

  • CAS No. 1558302-68-3
  • Cat. No. CS-0036837
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClN₃
  • Molecular Weight 167.60
  • Synonym(s) 6-chloro-1-methyl-pyrazolo[4,3-c]pyridine
  • SMILES CN1C2=C(C=NC(=C2)Cl)C=N1

Description

6-Chloro-1-methyl-1H-pyrazolo[4,3-c]pyridine features a chlorinated pyrazolopyridine core with enhanced electron-deficient character, enabling efficient coupling in cross-coupling reactions. The methyl group at the 1-position improves solubility and stability under standard conditions, while the chlorine serves as a reactive handle for palladium-catalyzed transformations. This scaffold integrates readily into complex heterocyclic architectures.

Application

6-Chloro-1-methyl-1H-pyrazolo[4,3-c]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to substituted pyrazolopyridines via palladium-catalyzed cross-coupling reactions. Its chlorine atom facilitates nucleophilic substitution under mild conditions, while the methyl group enhances solubility and metabolic stability. The scaffold exhibits excellent bench stability and compatibility with standard reaction workflows, making it ideal for rapid library synthesis and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   30.71
  • LogP   1.6217
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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