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Structure of 155377-05-2
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Methyl 6-(trifluoromethyl)picolinate features a trifluoromethyl group at the pyridine ring's 6-position, enhancing electron-withdrawing character and metabolic stability. This bench-stable ester integrates readily into synthetic sequences requiring fluorinated heterocycles, offering improved solubility and reactivity in transition metal-catalyzed couplings and nucleophilic substitutions.
Methyl 6-(trifluoromethyl)picolinate serves as a versatile building block in medicinal chemistry, enabling efficient access to trifluoromethylated heterocyclic scaffolds. Its pyridine core exhibits enhanced metabolic stability and modulated basicity, while the ester group facilitates downstream functionalization via hydrolysis, reduction, or coupling reactions. The trifluoromethyl moiety imparts favorable lipophilicity and bioavailability profiles, making it a practical choice for lead optimization campaigns in drug discovery.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: