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1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

  • CAS No. 15506-18-0

  • Cat. No. CS-0038255
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid|CS-0038255

Structure of 15506-18-0

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General Information

  • CAS No. 15506-18-0
  • Cat. No. CS-0038255
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) AJ-333/25006182
  • SMILES CN1C=CC=C(C1=O)C(=O)O

Description

1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid features a conjugated enamide system with a carboxylic acid group at the 3-position, enabling direct integration into heterocyclic scaffolds. The methyl substituent enhances solubility and stability under standard conditions, while the electron-deficient pyridine core facilitates nucleophilic addition and cycloaddition reactions in synthetic transformations.

Application

1-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyridine and pyridone scaffolds. Its conjugated enone system facilitates Michael additions and cycloadditions, while the carboxylic acid group supports direct derivatization or metal-catalyzed coupling reactions. The compound exhibits good bench stability and simplifies purification due to its crystalline nature, making it suitable for scalable medicinal chemistry campaigns and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.3
  • LogP   0.0835
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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