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(3R,5S)-tert-butyl 6-chloro-3,5-dihydroxyhexanoate Rosuvastatin Impurity

  • CAS No. 154026-93-4

  • Cat. No. CS-0165341
  • Purity95+%
  • MDL No.MFCD16876377

*For research and further manufacturing use only, not for direct human use.

(3R,5S)-tert-butyl 6-chloro-3,5-dihydroxyhexanoate  Rosuvastatin Impurity|CS-0165341

Structure of 154026-93-4

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General Information

  • CAS No. 154026-93-4
  • Cat. No. CS-0165341
  • Purity 95+%
  • MDL No. MFCD16876377
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉ClO₄
  • Molecular Weight 238.71
  • Synonym(s) tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate
  • SMILES O=C(OC(C)(C)C)C[C@H](O)C[C@H](O)CCl

Synthesis

  • Route1
    • null|null
      276249-18-4
    • ~95%
    • (3R,5S)-tert-butyl 6-chloro-3,5-dihydroxyhexanoate  Rosuvastatin Impurity|CS-0165341
      154026-93-4

    References

    • PHOENIX CHEMICALS LIMITED Patent: WO2003/97569 A1, 2003 ; Location in patent: Page/Page column 13-16 ;
  • Route2
    • (S)-tert-butyl 6-chloro-5-hydroxy-3-oxohexanoate  Rosuvastatin Impurity|CS-0165317
      154026-92-3
    • ~%
    • (3R,5S)-tert-butyl 6-chloro-3,5-dihydroxyhexanoate  Rosuvastatin Impurity|CS-0165341
      154026-93-4

    References

    • Wolberg, Michael; Hummel, Werner; Mueller, Michael Chemistry - A European Journal, 2001 , vol. 7, # 21 p. 4562 - 4571
  • Route3

    References

    • Wolberg, Michael; Hummel, Werner; Mueller, Michael Chemistry - A European Journal, 2001 , vol. 7, # 21 p. 4562 - 4571

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331-H341
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.76
  • LogP   1.0689
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   5

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