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CS-W001157 4
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1-(Azetidin-3-yl)-1H-imidazole dihydrochloride

  • CAS No. 153836-44-3

  • Cat. No. CS-W020483
  • Purity≥95%
  • MDL No.MFCD22056235

*For research and further manufacturing use only, not for direct human use.

1-(Azetidin-3-yl)-1H-imidazole dihydrochloride|CS-W020483

Structure of 153836-44-3

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General Information

  • CAS No. 153836-44-3
  • Cat. No. CS-W020483
  • Purity ≥95%
  • MDL No. MFCD22056235
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁Cl₂N₃
  • Molecular Weight 196.08
  • Synonym(s) None
  • SMILES [H]Cl.[H]Cl.N1(C2CNC2)C=CN=C1

Description

This imidazole derivative features a sterically constrained azetidine ring fused to an electron-deficient imidazole core, delivering enhanced metabolic stability and improved membrane permeability. The dihydrochloride salt form ensures excellent aqueous solubility and handling convenience under standard bench conditions.

Application

1-(Azetidin-3-yl)-1H-imidazole dihydrochloride serves as a versatile heterocyclic building block for medicinal chemistry campaigns, enabling rapid access to bioactive scaffolds through standard amine functionalization and coupling reactions. The azetidine moiety provides enhanced metabolic stability and membrane permeability, while the imidazole nitrogen atoms offer strong coordination capacity and hydrogen-bonding potential. Bench-stable and readily purified by recrystallization, it functions effectively in peptide conjugation, transition-metal-catalyzed transformations, and diversity-oriented synthesis workflows.

Safety Information

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Computational Chemistry Data

  • TPSA   29.85
  • LogP   0.871
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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