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CS-W001157 4
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S-Methyl thioacetate

  • CAS No. 1534-08-3

  • Cat. No. CS-0154991
  • Molecule weight90.14
  • Purity≥97%
  • MDL No.MFCD00014989

*For research and further manufacturing use only, not for direct human use.

S-Methyl thioacetate|CS-0154991

Structure of 1534-08-3

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General Information

  • CAS No. 1534-08-3
  • Cat. No. CS-0154991
  • Purity ≥97%
  • MDL No. MFCD00014989
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₆OS
  • Molecular Weight 90.14
  • Synonym(s) None
  • SMILES CC(=O)SC

Description

S-Methylthioacetate is a bench-stable thioester featuring a methylthio group that enhances nucleophilic reactivity. This electrophilic acylating agent integrates efficiently into synthetic sequences requiring selective acylation, particularly in peptide and heterocycle synthesis. The sulfur moiety enables facile displacement under mild conditions, delivering high functional group tolerance and clean reaction profiles.

Application

S-Methylthioacetate serves as a versatile thioester building block in synthetic organic chemistry, enabling efficient access to sulfide-containing intermediates and facilitating C–S bond formation under mild conditions. Its bench-stable nature and compatibility with a range of functional groups make it well-suited for use in multi-step syntheses, including the construction of heterocyclic scaffolds and cysteine-derived motifs.

Synthesis

  • Route1
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      22966-40-1
    • ~30%
    • In-stock
      S-Methyl thioacetate|CS-0154991
      1534-08-3

    References

    • Mikolajczyk, Marian; Midura, Wanda; Grzejszczak, Slawomir Tetrahedron Letters, 1984 , vol. 25, # 23 p. 2489 - 2492
  • Route2
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      463-51-4
    • null|null
      74-93-1
    • ~%
    • In-stock
      S-Methyl thioacetate|CS-0154991
      1534-08-3

    References

    • Journal of the American Chemical Society, , vol. 77, p. 4672
  • Route3
    • null|null
      81956-70-9
    • ~%
    • In-stock
      S-Methyl thioacetate|CS-0154991
      1534-08-3
    • null|null
      60193-28-4

    References

    • Journal of the American Chemical Society, , vol. 104, # 15 p. 4117 - 4124

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1992
Class : 3 (6.1)
Packing Group : Ⅱ
Hazard Statements : H225-H311-H319-H332
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P361+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   0.8959
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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