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CS-W001157 4
Total: USD 88.00

3-Azidopropyl 4-methylbenzenesulfonate

  • CAS No. 153207-76-2

  • Cat. No. CS-0438484
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Azidopropyl 4-methylbenzenesulfonate|CS-0438484

Structure of 153207-76-2

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General Information

  • CAS No. 153207-76-2
  • Cat. No. CS-0438484
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃N₃O₃S
  • Molecular Weight 255.29
  • Synonym(s) 1-azido-3-tosyloxypropane
  • SMILES [N-]=[N+]=NCCCOS(=O)(C1=CC=C(C)C=C1)=O

Description

3-Azidopropyl 4-methylbenzenesulfonate is a bench-stable, moisture-tolerant sulfonate ester featuring a terminal azide group. This reagent enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and materials functionalization. The para-methyl substituent enhances solubility in organic media while maintaining high reactivity.

Application

3-Azidopropyl 4-methylbenzenesulfonate serves as a versatile alkylating agent for introducing azido-functionalized propyl chains under mild conditions. Its sulfonate leaving group enables efficient displacement by nucleophiles, including amines and thiols, facilitating the construction of bioconjugation handles and functionalized heterocycles. The molecule exhibits good bench stability and ease of purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   92.13
  • LogP   2.40072
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   6

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