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(9H-Fluoren-9-yl)methyl (2-mercaptoethyl)carbamate

  • CAS No. 152835-00-2

  • Cat. No. CS-0613448
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(9H-Fluoren-9-yl)methyl (2-mercaptoethyl)carbamate|CS-0613448

Structure of 152835-00-2

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General Information

  • CAS No. 152835-00-2
  • Cat. No. CS-0613448
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₇NO₂S
  • Molecular Weight 299.39
  • Synonym(s) None
  • SMILES O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCS

Description

Fmoc-2-ME-Carbamate delivers a robust, moisture-tolerant protecting group for amine-directed synthesis. This stable derivative integrates seamlessly into peptide coupling workflows, offering efficient deprotection under mild conditions. The Fmoc moiety enables selective N-terminal protection, while the thioether linkage resists premature cleavage. Ideal for complex molecule assembly and solid-phase applications.

Application

(9H-Fluoren-9-yl)methyl (2-mercaptoethyl)carbamate serves as a robust thiol-directed protecting group for amines, enabling selective conjugation and orthogonal deprotection under mild conditions. Its fluorenyl moiety provides excellent UV detectability and facilitates clean removal via base-catalyzed cleavage. The molecule exhibits high bench stability, tolerates diverse functional groups, and functions efficiently in solid-phase synthesis and peptide modification workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   3.4549
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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