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CS-W001157 4
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(Chloromethyl)triethoxysilane

  • CAS No. 15267-95-5

  • Cat. No. CS-0086574
  • Purity≥96%
  • MDL No.MFCD00039354

*For research and further manufacturing use only, not for direct human use.

(Chloromethyl)triethoxysilane|CS-0086574

Structure of 15267-95-5

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General Information

  • CAS No. 15267-95-5
  • Cat. No. CS-0086574
  • Purity ≥96%
  • MDL No. MFCD00039354
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₇ClO₃Si
  • Molecular Weight 212.75
  • Synonym(s) triethoxy(chloromethyl)-silan
  • SMILES CCO[Si](OCC)(CCl)OCC

Description

(Chloromethyl)triethoxysilane features a reactive chloromethyl group tethered to a triethoxysilyl moiety, enabling direct grafting onto siliceous surfaces. This dual functionality facilitates robust covalent attachment in surface modification protocols. The molecule exhibits excellent stability under standard conditions and undergoes controlled hydrolysis to yield active silanol species for subsequent condensation reactions.

Application

(Chloromethyl)triethoxysilane serves as a versatile silyl-protected chloromethyl building block, enabling selective functionalization in complex molecule synthesis. Its stable triethoxysilyl group facilitates easy handling and purification, while the reactive chloromethyl moiety participates reliably in nucleophilic substitution reactions. This reagent functions effectively in the construction of silicon-directed synthetic intermediates and provides orthogonal protection in multi-step sequences, making it valuable for applications in medicinal chemistry and materials science.

Synthesis

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    • In-stock
      (Chloromethyl)triethoxysilane|CS-0086574
      15267-95-5

    References

    • Pomerantseva; Belyakova; Shryaev; Efimova; Sheludyakov Journal of applied chemistry of the USSR, 1986 , vol. 59, # 6 pt 2 p. 1314 - 1315
  • Route2
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      1558-25-4
    • ~%
    • In-stock
      (Chloromethyl)triethoxysilane|CS-0086574
      15267-95-5

    References

    • Journal of the American Chemical Society, , vol. 73, p. 3867 - 3871
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      64-17-5
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      63238-95-9
    • ~%
    • In-stock
      (Chloromethyl)triethoxysilane|CS-0086574
      15267-95-5

    References

    • Russian Journal of General Chemistry, , vol. 71, # 7 p. 1038 - 1040

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   1.8128
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   7

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