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CS-W001157 4
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(R)-(1,4-Dioxan-2-yl)methanamine hydrochloride

  • CAS No. 1523541-84-5

  • Cat. No. CS-0037059
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-(1,4-Dioxan-2-yl)methanamine hydrochloride|CS-0037059

Structure of 1523541-84-5

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General Information

  • CAS No. 1523541-84-5
  • Cat. No. CS-0037059
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO₂
  • Molecular Weight 153.61
  • Synonym(s) (R)-C-[1,4]Dioxan-2-yl-methylamine hydrochloride
  • SMILES C1CO[C@H](CN)CO1.Cl

Description

(R)-(1,4-Dioxan-2-yl)methanamine hydrochloride is a chiral amine scaffold featuring a rigid dioxane ring that enhances conformational stability. This bench-stable derivative integrates seamlessly into asymmetric synthesis and medicinal chemistry workflows, offering predictable stereocontrol in C–N bond formation.

Application

(R)-(1,4-Dioxan-2-yl)methanamine hydrochloride serves as a stable, bench-ready chiral building block for the synthesis of bioactive heterocycles and medicinal intermediates. Its amine functionality enables straightforward amidation, alkylation, and reductive amination reactions, while the 1,4-dioxane ring imparts favorable solubility and metabolic stability. The compound functions effectively in standard coupling protocols and supports orthogonal functionalization strategies in multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   44.48
  • LogP   -0.2177
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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