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CS-W001157 4
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(2R,4R)-Methyl 2-methylpiperidine-4-carboxylate hydrochloride

  • CAS No. 1523530-24-6

  • Cat. No. CS-0085708
  • Molecule weight193.67
  • Purity≥98%
  • MDL No.MFCD26959148

*For research and further manufacturing use only, not for direct human use.

(2R,4R)-Methyl 2-methylpiperidine-4-carboxylate hydrochloride|CS-0085708

Structure of 1523530-24-6

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General Information

  • CAS No. 1523530-24-6
  • Cat. No. CS-0085708
  • Purity ≥98%
  • MDL No. MFCD26959148
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆ClNO₂
  • Molecular Weight 193.67
  • Synonym(s) rac-methyl (2R,4R)-2-methylpiperidine-4-carboxylate hydrochloride, cis
  • SMILES O=C([C@H]1C[C@@H](C)NCC1)OC.Cl

Description

(2R,4R)-Methyl 2-methylpiperidine-4-carboxylate hydrochloride is a chiral piperidine derivative featuring a stereodefined quaternary center and a methyl ester group. This bench-stable salt delivers enhanced solubility and crystallinity, enabling efficient incorporation into asymmetric synthesis workflows.

Application

(2R,4R)-Methyl 2-methylpiperidine-4-carboxylate hydrochloride serves as a stereochemically defined building block for the synthesis of bioactive heterocycles and peptidomimetics. Its constrained piperidine core offers enhanced conformational control, while the methyl and ester functionalities enable diverse downstream transformations. The hydrochloride salt improves solubility and handling, facilitating use in standard coupling reactions, reductive aminations, and late-stage functionalizations common in medicinal chemistry workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   0.9693
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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