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CS-W001157 4
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3-(1-(tert-Butoxycarbonyl)azetidin-3-yl)propanoic acid

  • CAS No. 1521114-14-6

  • Cat. No. CS-0079042
  • Purity≥98%
  • MDL No.MFCD28388690

*For research and further manufacturing use only, not for direct human use.

3-(1-(tert-Butoxycarbonyl)azetidin-3-yl)propanoic acid|CS-0079042

Structure of 1521114-14-6

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General Information

  • CAS No. 1521114-14-6
  • Cat. No. CS-0079042
  • Purity ≥98%
  • MDL No. MFCD28388690
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₄
  • Molecular Weight 229.28
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CC(C1)CCC(=O)O

Description

This azetidine-containing carboxylic acid features a tert-butoxycarbonyl-protected amine, enabling stable incorporation into peptide chains. The propanoic acid side chain provides a flexible spacer for conjugation, while the strained azetidine ring imparts unique conformational rigidity. Ideal for medicinal chemistry applications requiring bioactive scaffold integration.

Application

3-(1-(tert-Butoxycarbonyl)azetidin-3-yl)propanoic acid serves as a versatile building block for the synthesis of azetidine-containing bioactive molecules. The tert-butyl ester group provides excellent stability and compatibility with standard peptide coupling conditions, enabling straightforward deprotection under mild acidic conditions. Its propanoic acid side chain facilitates conjugation via amide bond formation, supporting applications in medicinal chemistry and fragment-based drug discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.7181
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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