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CS-W001157 4
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O,O,O-Trimethyl phosphorothioate

  • CAS No. 152-18-1

  • Cat. No. CS-0001866
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

O,O,O-Trimethyl phosphorothioate|CS-0001866

Structure of 152-18-1

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General Information

  • CAS No. 152-18-1
  • Cat. No. CS-0001866
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₉O₃PS
  • Molecular Weight 156.14
  • Synonym(s) TRIMETHYLPHOSPHOROTHIONATE
  • SMILES S=P(OC)(OC)OC

Description

O,O,O-Trimethyl phosphorothioate is a bench-stable, moisture-tolerant organophosphorus reagent featuring a thiophosphoryl core. This compound integrates readily into synthetic sequences requiring selective sulfur transfer, enabling efficient incorporation of thioether functionalities in complex molecular architectures.

Application

O,O,O-Trimethyl phosphorothioate serves as a versatile sulfur-transfer reagent in synthetic organic chemistry, enabling efficient conversion of carbonyl groups to thiocarbonyls under mild conditions. Its stability, ease of handling, and compatibility with diverse functional groups make it a practical choice for bench-scale synthesis of thioesters, thioamides, and related heterocyclic scaffolds.

Synthesis

  • Route1

    References

    • Brown, R. Stanley; Neverov, Alexei A.; Tsang, Josephine S.W. Patent: US2004/230082 A1, 2004 ; Location in patent: Page 16 ;
  • Route2
    • null|null
      121-45-9
    • ~99%
    • In-stock
      O,O,O-Trimethyl phosphorothioate|CS-0001866
      152-18-1

    References

    • Brehon, Annick; Couture, Axel; Lablache-Combier, A. Journal de Chimie Physique et de Physico-Chimie Biologique, 1985 , vol. 82, # 9 p. 861 - 872
  • Route3
    • null|null
      121-45-9
    • ~4%
    • In-stock
      Trimethyl phosphate|CS-0646319
      512-56-1
    • In-stock
      O,O,O-Trimethyl phosphorothioate|CS-0001866
      152-18-1
    • null|null
      756-79-6

    References

    • Ando, Fumio; Koketsu, Jugo; Ishii, Yoshio Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 11 p. 3495 - 3499

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3278
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   1.1501
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

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