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CS-W001157 4
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4-Amino-3-fluorobenzenethiol

  • CAS No. 15178-48-0

  • Cat. No. CS-0103889
  • Purity≥95%
  • MDL No.MFCD09835280

*For research and further manufacturing use only, not for direct human use.

4-Amino-3-fluorobenzenethiol|CS-0103889

Structure of 15178-48-0

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General Information

  • CAS No. 15178-48-0
  • Cat. No. CS-0103889
  • Purity ≥95%
  • MDL No. MFCD09835280
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNS
  • Molecular Weight 143.18
  • Synonym(s) 4-Amino-3-fluorothiophenol
  • SMILES SC1=CC=C(N)C(F)=C1

Description

4-Amino-3-fluorobenzenethiol features a strategically positioned amino group flanked by fluorine and thiol functionalities, enabling selective conjugation in bioconjugation workflows. The electron-withdrawing fluorine enhances the nucleophilicity of the thiol, while the amino group offers a handle for further derivatization. This scaffold combines high reactivity with bench-stable handling properties.

Application

4-Amino-3-fluorobenzenethiol serves as a versatile building block in medicinal chemistry, enabling the synthesis of sulfonamide and thiourea derivatives through its reactive thiol and amino functionalities. Its ortho-fluoro substituent facilitates palladium-catalyzed cross-coupling reactions, while the bench-stable thiol group allows for selective derivatization under mild conditions. Functions effectively in the construction of heterocyclic scaffolds and bioactive molecules requiring dual functional handles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.6966
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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