(R)-(+)-Hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one

Name: (R)-(+)-Hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one
Brand: ChemScene
Availability: InStock
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CAS No. 151763-89-2
Cat. No. CS-0053990
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(R)-(+)-Hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one|CS-0053990

Structure of 151763-89-2

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General Information

CAS No. 151763-89-2
Cat. No. CS-0053990
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₂N₂O
Molecular Weight 140.18
Synonym(s) (R)-Hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one
SMILES O=C1CC[C@]2([H])CNCCN21

Description

(R)-(+)-Hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one is a chiral heterocyclic scaffold featuring a saturated pyrrolidine-pyrazine fusion with defined stereochemistry at the C6 position. This bench-stable, electron-rich core integrates readily into bioactive molecule design, serving as a privileged structure in medicinal chemistry for targeting protein-protein interactions and enzyme inhibition.

Application

(R)-(+)-Hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one serves as a versatile chiral building block for the synthesis of nitrogen-rich heterocycles and bioactive compounds. Its rigid, polycyclic scaffold exhibits excellent bench stability and functional group tolerance, enabling straightforward derivatization via amide formation, reductive amination, or metal-catalyzed coupling reactions. This compound facilitates the construction of complex scaffolds relevant to medicinal chemistry and natural product synthesis.

Synthesis

Route1
- 865717-09-5
- ~91%
- In-stock
  
  151763-89-2
References
- Neurotune AG Patent: EP2098526 A1, 2009 ; Location in patent: Page/Page column 12 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

TPSA 32.34
LogP -0.4194
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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(R)-(+)-Hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one

CAS No. 151763-89-2

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