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(S)-tert-Butyl 2-formylpiperidine-1-carboxylate

  • CAS No. 150521-32-7

  • Cat. No. CS-0005350
  • Purity≥95%
  • MDL No.MFCD06738713

*For research and further manufacturing use only, not for direct human use.

(S)-tert-Butyl 2-formylpiperidine-1-carboxylate|CS-0005350

Structure of 150521-32-7

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General Information

  • CAS No. 150521-32-7
  • Cat. No. CS-0005350
  • Purity ≥95%
  • MDL No. MFCD06738713
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₃
  • Molecular Weight 213.27
  • Synonym(s) tert-butyl (2S)-2-formylpiperidine-1-carboxylate
  • SMILES O=C(OC(C)(C)C)N(CCCC1)[C@@H]1C=O

Description

(S)-tert-Butyl 2-formylpiperidine-1-carboxylate features a chiral piperidine core with a formyl group at the C2 position, enabling direct functionalization in asymmetric synthesis. The tert-butyl ester provides stability and ease of deprotection under mild conditions. This building block integrates readily into complex molecular architectures requiring stereoselective transformations.

Application

(S)-tert-Butyl 2-formylpiperidine-1-carboxylate serves as a versatile chiral building block for the synthesis of piperidine-containing pharmaceuticals and natural products. The formyl group enables direct functionalization via nucleophilic additions, while the tert-butyl carbamate protects the nitrogen under standard conditions. Its bench-stable nature and compatibility with diverse reaction types facilitate efficient access to complex heterocyclic scaffolds in medicinal chemistry workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   1.9749
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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