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N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride

  • CAS No. 149436-41-9

  • Cat. No. CS-0150601
  • Molecule weight386.85
  • Purity≥98%
  • MDL No.MFCD12911398

*For research and further manufacturing use only, not for direct human use.

N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride|CS-0150601

Structure of 149436-41-9

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General Information

  • CAS No. 149436-41-9
  • Cat. No. CS-0150601
  • Purity ≥98%
  • MDL No. MFCD12911398
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₉ClN₂O₅S
  • Molecular Weight 386.85
  • Synonym(s) 2-{2-methoxy-4-[(methylsulfonyl)amino]-5-phenoxyphenyl}-2-oxoethanaminium chloride
  • SMILES COC1=C(C=C(C(=C1)NS(=O)(=O)C)OC2=CC=CC=C2)C(=O)CN.Cl

Description

N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride features a phenoxy-substituted aryl scaffold with dual polar functionalities: a methoxy group enhancing solubility and a sulfonamide moiety enabling hydrogen bonding. This bench-stable derivative integrates seamlessly into bioactive molecule scaffolds for medicinal chemistry applications.

Application

N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride serves as a versatile intermediate in medicinal chemistry, enabling the construction of complex heterocyclic scaffolds through standard amide coupling and cyclization protocols. Its methanesulfonamide group enhances solubility and metabolic stability, while the phenolic ether and aminoacetyl functionalities support diverse downstream modifications. The hydrochloride salt ensures excellent bench stability and ease of handling in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   107.72
  • LogP   2.4222
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   7

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