Mal-L-PA-NH-Boc

Name: Mal-L-PA-NH-Boc
Brand: ChemScene
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CAS No. 1491152-23-8
Cat. No. CS-0019471
Molecule weight284.27
Purity≥95%
MDL No.MFCD28100921

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1491152-23-8
Cat. No. CS-0019471
Purity ≥95%
MDL No. MFCD28100921
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₆N₂O₆
Molecular Weight 284.27
Synonym(s) mDPR(boc); (S)-MALEOYL-DPR(BOC)-OH·DCHA
SMILES O=C(C=C1)N([C@@H](CNC(OC(C)(C)C)=O)C(O)=O)C1=O

Description

Mal-L-PA-NH-Boc is a bifunctional peptide coupling reagent featuring a maleimide group for site-specific bioconjugation and a Boc-protected amine for orthogonal functionalization. This compound enables efficient, selective conjugation under physiological conditions while maintaining stability during synthesis and storage.

Application

Mal-L-PA-NH-Boc serves as a versatile dipeptide building block for peptide synthesis, enabling efficient incorporation of malonyl-protected lysine derivatives. The Boc group provides orthogonal protection for the amine, facilitating selective deprotection and coupling in multi-step sequences. Its stability under standard synthetic conditions and compatibility with common coupling reagents support reliable use in solid-phase and solution-phase peptide assembly.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 113.01
LogP -0.1107
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 4

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrroline compounds

Life Science Linker Maleimide Linkers

Life Science ADC Related Compound Non-cleavable linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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Mal-L-PA-NH-Boc

CAS No. 1491152-23-8

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