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CS-W001157 4
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L-Homocysteic acid

  • CAS No. 14857-77-3

  • Cat. No. CS-0173310
  • Purity≥98%
  • MDL No.MFCD00066018

*For research and further manufacturing use only, not for direct human use.

L-Homocysteic acid|CS-0173310

Structure of 14857-77-3

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General Information

  • CAS No. 14857-77-3
  • Cat. No. CS-0173310
  • Purity ≥98%
  • MDL No. MFCD00066018
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉NO₅S
  • Molecular Weight 183.18
  • Synonym(s) L-HCA
  • SMILES O=C(O)[C@@H](N)CCS(=O)(O)=O

Description

Inducing excitotoxicity via NMDA receptor activation at EC50 of 14 μM, L-Homocysteic acid (CAS 14857-77-3) drives neuronal degeneration in models of neurodegenerative pathology.

Application

L-Homocysteic acid (CAS 14857-77-3) drives research into hydrogen peroxide-induced oxidative stress within neural tissues, revealing key mechanisms behind neurodegenerative progression. It mimics pathological redox shifts in real time. Scientists use this compound to dissect how reactive oxygen species disrupt neuronal integrity and trigger cell death pathways.

Synthesis

  • Route1

    References

    • Nomoto, Shinya; Shimoyama, Akira; Shiraishi, Susumu Tetrahedron Letters, 1998 , vol. 39, # 9 p. 1009 - 1012
  • Route2

    References

    • Nomoto, Shinya; Shimoyama, Akira; Shiraishi, Susumu Tetrahedron Letters, 1998 , vol. 39, # 9 p. 1009 - 1012
  • Route3

    References

    • Nomoto, Shinya; Shimoyama, Akira; Shiraishi, Susumu Tetrahedron Letters, 1998 , vol. 39, # 9 p. 1009 - 1012

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   117.69
  • LogP   -1.3238
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   4

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