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CS-W001157 4
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2-(Trifluoromethyl)terephthalic acid

  • CAS No. 1483-47-2

  • Cat. No. CS-0157134
  • Purity≥98%
  • MDL No.MFCD06208277

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)terephthalic acid|CS-0157134

Structure of 1483-47-2

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General Information

  • CAS No. 1483-47-2
  • Cat. No. CS-0157134
  • Purity ≥98%
  • MDL No. MFCD06208277
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅F₃O₄
  • Molecular Weight 234.13
  • Synonym(s) 2-(Trifluoromethyl)-1,4-Benzenedicarboxylic acid
  • SMILES O=C(O)C1=CC=C(C(=O)O)C(=C1)C(F)(F)F

Description

2-(Trifluoromethyl)terephthalic acid is a sterically hindered, electron-deficient aromatic diacid featuring a trifluoromethyl group at the para position. This substitution enhances metabolic stability and modulates electronic properties, making it ideal for constructing robust coordination frameworks and functional polymers in materials science and medicinal chemistry applications.

Application

2-(Trifluoromethyl)terephthalic acid serves as a versatile building block for constructing functionalized aromatic scaffolds in medicinal chemistry and materials science. Its dual carboxylic acid groups enable efficient amide, ester, and polymer linkages, while the electron-withdrawing trifluoromethyl group enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and facilitates straightforward purification via recrystallization, making it well-suited for high-throughput synthesis and scale-up applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   74.6
  • LogP   2.1018
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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