Ac-Lys(Fmoc)-OH

Name: Ac-Lys(Fmoc)-OH
Brand: ChemScene
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CAS No. 148101-51-3
Cat. No. CS-0154010
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 148101-51-3
Cat. No. CS-0154010
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₂₆N₂O₅
Molecular Weight 410.46
Synonym(s) N-alpha-Ac-Nε-2-Fmoc-L-lysine
SMILES CC(N[C@H](C(O)=O)CCCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O

Description

Ac-Lys(Fmoc)-OH is a protected lysine derivative featuring a fluorenylmethoxycarbonyl (Fmoc) group on the ε-amino function and an acetyl block on the α-amino terminus. This dual protection enables orthogonal handling in solid-phase peptide synthesis, where the Fmoc moiety allows for selective deprotection under mild basic conditions while preserving the acetyl group. The compound integrates cleanly into growing peptide chains with minimal side reactivity, offering high stability during storage and handling.

Application

Ac-Lys(Fmoc)-OH serves as a key building block in peptide synthesis, enabling the incorporation of protected lysine residues with orthogonal side-chain functionality. The Fmoc group ensures efficient removal under mild basic conditions, while the acetyl protection on the α-amino group provides stability and prevents undesired coupling. This derivative facilitates sequence-specific elongation in solid-phase and solution-phase syntheses, offering excellent solubility and compatibility with standard coupling reagents.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 104.73
LogP 3.2847
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 9

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Ac-Lys(Fmoc)-OH

CAS No. 148101-51-3

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