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CS-W001157 4
Total: USD 88.00

6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine

  • CAS No. 1480-66-6

  • Cat. No. CS-0054511
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine|CS-0054511

Structure of 1480-66-6

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General Information

  • CAS No. 1480-66-6
  • Cat. No. CS-0054511
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClF₃N₃
  • Molecular Weight 197.55
  • Synonym(s) 6-Chloro-2-trifluoromethylpyrimidin-4-ylamine
  • SMILES NC1=NC(C(F)(F)F)=NC(Cl)=C1

Description

6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine is a bench-stable heterocyclic building block featuring a chlorine substituent and a trifluoromethyl group at electron-deficient positions. This combination enhances reactivity in cross-coupling processes, enabling efficient incorporation into pharmaceutical scaffolds and agrochemical intermediates under standard conditions.

Application

6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its chloro group facilitates nucleophilic substitution reactions with amines and thiols, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity. The amine functionality supports direct coupling or derivatization, offering broad utility in API development. Bench-stable and readily purified, it functions reliably in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.731
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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