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CS-W001157 4
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6-Chloro-2-methylimidazo[1,2-b]pyridazine

  • CAS No. 14793-00-1

  • Cat. No. CS-W006591
  • Purity≥96%
  • MDL No.MFCD07778346

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-methylimidazo[1,2-b]pyridazine|CS-W006591

Structure of 14793-00-1

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General Information

  • CAS No. 14793-00-1
  • Cat. No. CS-W006591
  • Purity ≥96%
  • MDL No. MFCD07778346
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClN₃
  • Molecular Weight 167.60
  • Synonym(s) 6-chloro-2-Methyl-iMidazopyridazine
  • SMILES CC1=CN2N=C(Cl)C=CC2=N1

Description

6-Chloro-2-methylimidazo[1,2-b]pyridazine is a heterocyclic scaffold featuring a chlorinated imidazopyridazine core with a methyl group at the 2-position. This electron-deficient system enables efficient coupling in transition-metal-catalyzed cross-coupling reactions and serves as a key building block in medicinal chemistry for targeted drug discovery programs.

Application

6-Chloro-2-methylimidazo[1,2-b]pyridazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of bioactive scaffolds. Its chloro substituent facilitates nucleophilic substitution and palladium-catalyzed coupling reactions, while the methyl group enhances solubility and modulates electronic properties. The imidazo[1,2-b]pyridazine core exhibits favorable stability under standard reaction conditions, supporting straightforward purification and integration into complex molecular architectures.

Synthesis

  • Route1
    • In-stock
      3-Amino-6-chloropyridazine|CS-W019657
      5469-69-2
    • null|null
      78-95-5
    • ~50%
    • In-stock
      6-Chloro-2-methylimidazo[1,2-b]pyridazine|CS-W006591
      14793-00-1

    References

    • Mourad; Wise; Townsend Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1365 - 1372

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   1.69112
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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