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CS-W001157 4
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tert-Butyl azetidine-1-carboxylate

  • CAS No. 147621-21-4

  • Cat. No. CS-0079053
  • Purity≥98%
  • MDL No.MFCD09264397

*For research and further manufacturing use only, not for direct human use.

tert-Butyl azetidine-1-carboxylate|CS-0079053

Structure of 147621-21-4

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General Information

  • CAS No. 147621-21-4
  • Cat. No. CS-0079053
  • Purity ≥98%
  • MDL No. MFCD09264397
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO₂
  • Molecular Weight 157.21
  • Synonym(s) 1-(TERT-BUTOXYCARBONYL)AZETIDINE
  • SMILES O=C(N1CCC1)OC(C)(C)C

Description

tert-Butyl azetidine-1-carboxylate delivers a strained, four-membered azetidine ring with enhanced nucleophilicity and metabolic stability. This bench-stable carbamate protects the primary amine in peptide synthesis and enables efficient incorporation into bioactive scaffolds. The tert-butyl group facilitates straightforward deprotection under mild acidic conditions, streamlining access to functionalized azetidines for medicinal chemistry applications.

Application

tert-Butyl azetidine-1-carboxylate serves as a stable, bench-ready building block for the synthesis of azetidine-containing scaffolds. Its protected amine functionality enables orthogonal handling in multi-step sequences, while the strained four-membered ring facilitates nucleophilic ring-opening reactions. It functions effectively in standard coupling protocols and supports the construction of bioactive heterocycles relevant to medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   1.6272
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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