N-Methoxy-N-methylcyclopropanecarboxamide

Name: N-Methoxy-N-methylcyclopropanecarboxamide
Brand: ChemScene
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CAS No. 147356-78-3
Cat. No. CS-0048809
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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N-Methoxy-N-methylcyclopropanecarboxamide|CS-0048809

Structure of 147356-78-3

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General Information

CAS No. 147356-78-3
Cat. No. CS-0048809
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₁NO₂
Molecular Weight 129.16
Synonym(s) N-Methoxy-N-methyl-cyclopropanecarboxamide
SMILES CON(C)C(=O)C1CC1

Description

N-Methoxy-N-methylcyclopropanecarboxamide delivers a strained cyclopropane ring fused to a polar amide moiety, enabling direct functionalization at the alkylated carbon. This bench-stable scaffold integrates readily into synthetic sequences requiring constrained aliphatic frameworks with tunable reactivity.

Application

N-Methoxy-N-methylcyclopropanecarboxamide serves as a stable, bench-ready acylating agent that facilitates efficient amide bond formation under mild conditions. Its cyclopropyl backbone imparts structural rigidity and enhanced functional group tolerance, enabling reliable coupling in complex molecule synthesis. The N-alkoxy substitution promotes controlled reactivity and simplifies purification, making it particularly useful for iterative peptide and heterocycle construction in medicinal chemistry workflows.

Synthesis

Route1
- In-stock
  
  6638-79-5
- 4023-34-1
- ~62%
- In-stock
  
  147356-78-3
References
- F. HOFFMANN-LA ROCHE AG Patent: WO2005/94828 A1, 2005 ; Location in patent: Page/Page column 19 ; WO 2005/094828 A1
Route2
- 276238-61-0
- ~74%
- In-stock
  
  147356-78-3
References
- Satyamurthi; Singh, Jaimala; Aidhen, Indrapal Singh Synthesis, 2000 , # 3 p. 375 - 382

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 29.54
LogP 0.4162
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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N-Methoxy-N-methylcyclopropanecarboxamide

CAS No. 147356-78-3

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