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CS-W001157 4
Total: USD 88.00

4-Bromo-2-chloro-5-(difluoromethyl)pyridine

  • CAS No. 1471259-57-0

  • Cat. No. CS-0498399
  • Purity≥96%
  • MDL No.MFCD25477654

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-chloro-5-(difluoromethyl)pyridine|CS-0498399

Structure of 1471259-57-0

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General Information

  • CAS No. 1471259-57-0
  • Cat. No. CS-0498399
  • Purity ≥96%
  • MDL No. MFCD25477654
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClF₂N
  • Molecular Weight 242.45
  • Synonym(s) None
  • SMILES FC(C1=CN=C(Cl)C=C1Br)F

Description

4-Bromo-2-chloro-5-(difluoromethyl)pyridine features a uniquely activated pyridine core with orthogonal halogen handles and a strongly electron-withdrawing difluoromethyl group. This combination enables direct cross-coupling or nucleophilic substitution under mild conditions, streamlining access to complex fluorinated heterocycles in medicinal chemistry and agrochemical synthesis.

Application

4-Bromo-2-chloro-5-(difluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogenation pattern. The difluoromethyl group enhances metabolic stability and modulates electronic properties, while the ortho-halogen substitution supports sequential functionalization. Bench-stable and compatible with standard reaction conditions, it facilitates efficient access to complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.4351
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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