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CS-W001157 4
Total: USD 88.00

Morpholino(phenyl)methanone

  • CAS No. 1468-28-6

  • Cat. No. CS-0051030
  • Purity≥98%
  • MDL No.MFCD00188446

*For research and further manufacturing use only, not for direct human use.

Morpholino(phenyl)methanone|CS-0051030

Structure of 1468-28-6

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General Information

  • CAS No. 1468-28-6
  • Cat. No. CS-0051030
  • Purity ≥98%
  • MDL No. MFCD00188446
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃NO₂
  • Molecular Weight 191.23
  • Synonym(s) 4-Benzoylmorpholine
  • SMILES O=C(N1CCOCC1)C1=CC=CC=C1

Description

Morpholino(phenyl)methanone features a morpholine ring conjugated to a phenyl-substituted carbonyl group, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for targeting protein-protein interactions and enzyme inhibition.

Application

Morpholino(phenyl)methanone serves as a versatile benzoyl equivalent in synthetic organic chemistry, enabling efficient amide bond formation under mild conditions. Its morpholine ring enhances solubility and stability, while the phenyl group provides predictable reactivity in nucleophilic acyl substitution. This compound functions reliably in peptide coupling and heterocycle synthesis, offering clean reaction profiles and straightforward purification—ideal for bench-scale applications in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      110-91-8
    • null|null
      201230-82-2
    • null|null
      108-90-7
    • ~51%
    • In-stock
      Morpholino(phenyl)methanone|CS-0051030
      1468-28-6

    References

    • Prasad, Aitha Vishwa; Biying, Algin Oh; Ling, Woo Yuan; Stubbs, Ludger Paul; Zhu, Yinghuai Journal of Polymer Science, Part A: Polymer Chemistry, 2013 , vol. 51, # 19 p. 4167 - 4174
  • Route2
    • null|null
      110-91-8
    • In-stock
      Iodobenzene|CS-W008603
      591-50-4
    • null|null
      201230-82-2
    • ~%
    • In-stock
      Morpholino(phenyl)methanone|CS-0051030
      1468-28-6
    • null|null
      40991-78-4

    References

    • Journal of Molecular Catalysis A: Chemical, , vol. 378, p. 193 - 199
  • Route3
    • 2-Morpholino-2-phenylacetonitrile|CS-0171253
      15190-10-0
    • ~73%
    • In-stock
      Morpholino(phenyl)methanone|CS-0051030
      1468-28-6

    References

    • Yokoshima, Satoshi; Kubo, Tetsuji; Tokuyama, Hidetoshi; Fukuyama, Tohru Chemistry Letters, 2002 , # 2 p. 122 - 123

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   1.159
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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