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CS-W001157 4
Total: USD 88.00

(1R,2R)-N-Boc-1,2-cyclohexanediamine

  • CAS No. 146504-07-6

  • Cat. No. CS-D0336
  • Purity≥97%
  • MDL No.MFCD08726023

*For research and further manufacturing use only, not for direct human use.

(1R,2R)-N-Boc-1,2-cyclohexanediamine|CS-D0336

Structure of 146504-07-6

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General Information

  • CAS No. 146504-07-6
  • Cat. No. CS-D0336
  • Purity ≥97%
  • MDL No. MFCD08726023
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight 214.30
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N[C@H]1[C@H](N)CCCC1

Application

(1R,2R)-N-Boc-1,2-cyclohexanediamine serves as a chiral diamine building block for asymmetric synthesis, enabling the construction of enantioselective catalysts and ligands. Its bench-stable Boc protection facilitates handling and purification, while the rigid cyclohexane backbone provides defined stereochemistry for high diastereoselectivity in metal-catalyzed transformations. Functions effectively in amine coupling reactions and as a scaffold for bioactive heterocycles.

Synthesis

  • Route1
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      20439-47-8
    • ~91%
    • In-stock
      (1R,2R)-N-Boc-1,2-cyclohexanediamine|CS-D0336
      146504-07-6

    References

    • Uppadine; Keene; Beer Journal of the Chemical Society, Dalton Transactions, 2001 , # 14 p. 2188 - 2198
  • Route2
    • null|null
      315179-47-6
    • ~98%
    • In-stock
      (1R,2R)-N-Boc-1,2-cyclohexanediamine|CS-D0336
      146504-07-6

    References

    • Kim, Young Kook; Lee, Seok Jong; Ahn, Kyo Han Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7807 - 7813
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 65, # 23 p. 7807 - 7813

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   1.781
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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