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Structure of 146328-87-2
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5-Cyano-2-fluorobenzoic acid features a strategically positioned cyano group flanking a fluorinated benzene ring, delivering enhanced electron-withdrawal and metabolic stability. This combination enables efficient incorporation into bioactive scaffolds, particularly in kinase inhibitor design and PET tracer development. The carboxylic acid moiety facilitates conjugation under standard coupling conditions.
5-Cyano-2-fluorobenzoic acid serves as a versatile building block in medicinal chemistry and materials science, enabling direct incorporation of electron-withdrawing cyano and fluorine substituents into aromatic scaffolds. Its carboxylic acid functionality facilitates amide coupling, esterification, and salt formation, while the ortho-fluoro and meta-cyano groups offer enhanced metabolic stability and tunable electronic properties. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for use in standard synthetic workflows targeting bioactive heterocycles and functionalized aryl systems.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: