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CS-W001157 4
Total: USD 88.00

2,6-Dimethoxybenzenesulfonyl chloride

  • CAS No. 145980-89-8

  • Cat. No. CS-0102929
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,6-Dimethoxybenzenesulfonyl chloride|CS-0102929

Structure of 145980-89-8

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General Information

  • CAS No. 145980-89-8
  • Cat. No. CS-0102929
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClO₄S
  • Molecular Weight 236.67
  • Synonym(s) 2,6-Dimethoxybenzenesulfonylchloride
  • SMILES O=S(C1=C(OC)C=CC=C1OC)(Cl)=O

Description

2,6-Dimethoxybenzenesulfonyl chloride features a sulfonyl chloride group flanked by two methoxy substituents at the 2 and 6 positions of the benzene ring. This electron-rich, sterically hindered architecture enhances reactivity while improving stability under standard handling conditions. The compound serves as a selective sulfonating agent in synthetic transformations, enabling efficient incorporation of sulfonyl moieties into complex molecular frameworks.

Application

2,6-Dimethoxybenzenesulfonyl chloride serves as a robust sulfonylating agent for the synthesis of sulfonamide derivatives and sulfonate esters. Its ortho-dimethoxy substitution enhances electrophilicity while improving solubility in polar organic solvents. The compound exhibits excellent bench stability and facilitates clean reactions with amines and alcohols under mild conditions, enabling efficient access to functionalized intermediates for medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H335
Precautionary Statements : P260-P264-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   1.6313
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

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