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CS-W001157 4
Total: USD 88.00

Biotin-PEG4-alkyne

  • CAS No. 1458576-00-5

  • Cat. No. CS-0114530
  • Purity≥97%
  • MDL No.MFCD22380755

*For research and further manufacturing use only, not for direct human use.

Biotin-PEG4-alkyne|CS-0114530

Structure of 1458576-00-5

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General Information

  • CAS No. 1458576-00-5
  • Cat. No. CS-0114530
  • Purity ≥97%
  • MDL No. MFCD22380755
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₃₅N₃O₆S
  • Molecular Weight 457.58
  • Synonym(s) None
  • SMILES O=C(NCCOCCOCCOCCOCC#C)CCCC[C@H]1SC[C@@]([C@@]1([H])N2)([H])NC2=O

Description

Biotin-PEG4-alkyne features a short, hydrophilic PEG4 spacer flanking a terminal alkyne group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation. The biotin moiety provides high-affinity binding to streptavidin and avidin, while the PEG4 linker enhances solubility and reduces non-specific interactions. This bifunctional reagent streamlines site-specific labeling in protein and nucleic acid conjugations under standard conditions.

Application

Biotin-PEG4-alkyne serves as a versatile bifunctional linker for bioconjugation, enabling site-specific labeling via copper-catalyzed azide-alkyne cycloaddition (CuAAC). The PEG4 spacer provides enhanced solubility and reduced steric hindrance, while the alkyne group offers high reactivity with azides under mild conditions. This reagent facilitates efficient immobilization or detection of biomolecules in pull-down assays, affinity purification, and fluorescent labeling workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   107.15
  • LogP   0.528
  • H_Acceptors   7
  • H_Donors   3
  • Rotatable_Bonds   18

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