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CS-W001157 4
Total: USD 88.00

(3-(Hydroxymethyl)-4-methylphenyl)boronic acid

  • CAS No. 1451391-54-0

  • Cat. No. CS-0059161
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-(Hydroxymethyl)-4-methylphenyl)boronic acid|CS-0059161

Structure of 1451391-54-0

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General Information

  • CAS No. 1451391-54-0
  • Cat. No. CS-0059161
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁BO₃
  • Molecular Weight 165.98
  • Synonym(s) [3-(Hydroxymethyl)-4-methylphenyl]boronic acid
  • SMILES CC1=CC=C(B(O)O)C=C1CO

Description

This boronic acid features a hydroxymethyl group adjacent to the boronate, enhancing solubility and stability. The para-methyl substitution provides electron-donating character, improving coupling efficiency in Suzuki-Miyaura reactions. Bench-stable under standard conditions, it integrates seamlessly into complex molecule synthesis workflows.

Application

(3-(Hydroxymethyl)-4-methylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-hydroxymethyl and meta-methyl groups provide enhanced solubility and functional group tolerance, while the boronic acid moiety exhibits excellent bench stability and ease of purification—ideal for iterative synthesis of complex aromatic scaffolds and pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.83288
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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