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CS-W001157 4
Total: USD 88.00

3-Bromo-5-iodopyrazin-2-amine

  • CAS No. 1449112-32-6

  • Cat. No. CS-0105317
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-iodopyrazin-2-amine|CS-0105317

Structure of 1449112-32-6

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General Information

  • CAS No. 1449112-32-6
  • Cat. No. CS-0105317
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃BrIN₃
  • Molecular Weight 299.90
  • Synonym(s) None
  • SMILES NC1=NC=C(I)N=C1Br

Description

3-Bromo-5-iodopyrazin-2-amine delivers a dual halogenated pyrazine scaffold ideal for palladium-catalyzed cross-coupling. The ortho-bromine and para-iodine substituents enable sequential functionalization, while the pyrazine nitrogen atoms provide strong coordination sites. This compound exhibits excellent stability under standard bench conditions and facilitates rapid diversification in medicinal chemistry and materials synthesis.

Application

3-Bromo-5-iodopyrazin-2-amine serves as a versatile dihalogenated pyrazine building block for palladium-catalyzed cross-coupling reactions. Its orthogonal halogen reactivity enables sequential functionalization at the 3- and 5-positions, facilitating the construction of complex heterocyclic scaffolds. The compound exhibits excellent bench stability and is compatible with standard reaction conditions, making it ideal for iterative synthesis in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.4259
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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