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Thiazolo[4,5-b]pyridine-6-carboxylic acid

  • CAS No. 1448852-06-9

  • Cat. No. CS-0527195
  • Molecule weight180.18
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Thiazolo[4,5-b]pyridine-6-carboxylic acid|CS-0527195

Structure of 1448852-06-9

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General Information

  • CAS No. 1448852-06-9
  • Cat. No. CS-0527195
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄N₂O₂S
  • Molecular Weight 180.18
  • Synonym(s) None
  • SMILES O=C(C1=CN=C2C(SC=N2)=C1)O

Description

Thiazolo[4,5-b]pyridine-6-carboxylic acid features a fused heterocyclic core combining thiazole and pyridine rings, delivering enhanced electronic delocalization and rigidity. The carboxylic acid group enables direct conjugation or derivatization, supporting its use in bioactive molecule design and materials chemistry. This scaffold exhibits favorable solubility and stability under standard conditions.

Application

Thiazolo[4,5-b]pyridine-6-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its rigid fused scaffold provides enhanced metabolic stability and favorable electronic properties, while the carboxylic acid functionality enables straightforward derivatization via amide coupling, esterification, or salt formation. The compound exhibits good bench stability and facilitates purification through standard chromatographic techniques, making it well-suited for use in high-throughput synthesis and structure–activity relationship studies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   1.3895
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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