(R)-2-Amino-N-methyl-3-phenylpropanamide

Name: (R)-2-Amino-N-methyl-3-phenylpropanamide
Brand: ChemScene
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CAS No. 144836-90-8
Cat. No. CS-0098050
Molecule weight178.23
Purity≥95%
MDL No.MFCD12198421

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-2-Amino-N-methyl-3-phenylpropanamide|CS-0098050

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General Information

CAS No. 144836-90-8
Cat. No. CS-0098050
Purity ≥95%
MDL No. MFCD12198421
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₄N₂O
Molecular Weight 178.23
Synonym(s) R-α-aMino-N-Methyl-BenzenepropanaMide
SMILES O=C(NC)[C@H](N)CC1=CC=CC=C1

Description

(R)-2-Amino-N-methyl-3-phenylpropanamide is a chiral amino acid derivative featuring a phenyl-substituted aliphatic chain and a methylated amide group. This configuration imparts enhanced metabolic stability and favorable binding affinity in peptide-based drug discovery, particularly for targeting neurotransmitter receptors. The molecule integrates readily into peptidomimetic scaffolds due to its defined stereochemistry and solubility under standard conditions.

Application

(R)-2-Amino-N-methyl-3-phenylpropanamide serves as a key chiral building block for synthesizing bioactive molecules, particularly in the development of peptidomimetics and CNS-targeted therapeutics. Its well-defined stereochemistry enables reliable incorporation into complex scaffolds, while the N-methyl amide functionality enhances metabolic stability and membrane permeability. The compound exhibits good bench stability and compatibility with standard coupling protocols, facilitating efficient peptide elongation and diversification.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 55.12
LogP 0.3024
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Amide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-2-Amino-N-methyl-3-phenylpropanamide

CAS No. 144836-90-8

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