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CS-W001157 4
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5-(Trifluoromethyl)quinolin-7-amine

  • CAS No. 1447606-61-2

  • Cat. No. CS-0446601
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethyl)quinolin-7-amine|CS-0446601

Structure of 1447606-61-2

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General Information

  • CAS No. 1447606-61-2
  • Cat. No. CS-0446601
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇F₃N₂
  • Molecular Weight 212.17
  • Synonym(s) 5-(Trifluoromethyl)-7-quinolinamine
  • SMILES C1=CC2=C(C=C(C=C2N=C1)N)C(F)(F)F

Description

5-(Trifluoromethyl)quinolin-7-amine features a trifluoromethyl group at the 5-position and an amino functionality at the 7-position of the quinoline scaffold. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct incorporation into bioactive molecules through facile coupling reactions. The compound exhibits enhanced metabolic stability and improved membrane permeability compared to non-fluorinated analogs.

Application

5-(Trifluoromethyl)quinolin-7-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the amine functionality facilitates derivatization via amidation, alkylation, or electrophilic substitution. The compound exhibits good bench stability and compatibility with common purification methods, making it well-suited for iterative synthetic campaigns targeting kinase inhibitors and other pharmaceutical scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.8358
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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