Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Methyl 2-bromo-6-(trifluoromethyl)nicotinate

  • CAS No. 144740-56-7

  • Cat. No. CS-0463795
  • Purity≥97%
  • MDL No.MFCD12025861

*For research and further manufacturing use only, not for direct human use.

Methyl 2-bromo-6-(trifluoromethyl)nicotinate|CS-0463795

Structure of 144740-56-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 144740-56-7
  • Cat. No. CS-0463795
  • Purity ≥97%
  • MDL No. MFCD12025861
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrF₃NO₂
  • Molecular Weight 284.03
  • Synonym(s) Methyl 2-bromo-6-(trifluoromethyl)pyridine-3-carboxylate, 2-Bromo-3-(methoxycarbonyl)-6-(trifluoromethyl)pyridine
  • SMILES COC(=O)C1=C(Br)N=C(C=C1)C(F)(F)F

Description

Methyl 2-bromo-6-(trifluoromethyl)nicotinate is a halogenated heterocyclic ester featuring a bromine atom at the 2-position and a trifluoromethyl group at the 6-position of the nicotinate ring. This combination imparts strong electron-withdrawing character and enhanced metabolic stability, enabling its use in cross-coupling reactions and as a building block for bioactive compounds. The methyl ester facilitates further functionalization under mild conditions.

Application

Methyl 2-bromo-6-(trifluoromethyl)nicotinate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its bromo and ester functionalities. The trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient access to complex pyridine-based scaffolds.

Synthesis

  • Route1
    • null|null
      1001924-23-7
    • ~%
    • In-stock
      Methyl 2-bromo-6-(trifluoromethyl)nicotinate|CS-0463795
      144740-56-7

    References

    • WO2008/6540 A1, ; Page/Page column 55 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.6495
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 144740-56-7 sigma144740-56-7 manufacturer144740-56-7 price144740-56-7 structure144740-56-7 SDSbuy 144740-56-7144740-56-7 supplier144740-56-7 uses144740-56-7 molecular weightprice of 144740-56-7144740-56-7 chemical name formula of 144740-56-7
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label