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CS-W001157 4
Total: USD 88.00

4-Bromo-6-methyl-1-(4-methylbenzenesulfonyl)-1H,6H,7H-pyrrolo[2,3-c]pyridin-7-one

  • CAS No. 1445993-87-2

  • Cat. No. CS-W000118
  • Molecule weight381.24
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-6-methyl-1-(4-methylbenzenesulfonyl)-1H,6H,7H-pyrrolo[2,3-c]pyridin-7-one|CS-W000118

Structure of 1445993-87-2

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General Information

  • CAS No. 1445993-87-2
  • Cat. No. CS-W000118
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₃BrN₂O₃S
  • Molecular Weight 381.24
  • Synonym(s) 7H-Pyrrolo[2,3-c]pyridin-7-one, 4-bromo-1,6-dihydro-6-methyl-1-[(4-methylphenyl)sulfonyl]-
  • SMILES Cc1ccc(cc1)S(=O)(=O)n1ccc2c(Br)cn(C)c(=O)c12

Description

4-Bromo-6-methyl-1-(4-methylbenzenesulfonyl)-1H,6H,7H-pyrrolo[2,3-c]pyridin-7-one features a sterically hindered pyrrolopyridinone core bearing a bromine at C4 and a methyl group at C6, enabling facile downstream functionalization. The para-methylbenzenesulfonyl moiety enhances solubility and stability under standard conditions, facilitating integration into complex molecular architectures.

Application

4-Bromo-6-methyl-1-(4-methylbenzenesulfonyl)-1H,6H,7H-pyrrolo[2,3-c]pyridin-7-one serves as a versatile building block for constructing complex heterocyclic scaffolds in medicinal chemistry. The molecule combines a bromo handle for late-stage functionalization via palladium-catalyzed cross-coupling, a methyl group enabling further derivatization, and a robust 1-(4-methylbenzenesulfonyl) protection that enhances stability and facilitates purification. Its structure supports efficient access to diverse pyrrolopyridine-based architectures relevant to kinase inhibitor development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.07
  • LogP   2.64792
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

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