tert-Butyl 2-hydroxy-7-azaspiro[3.6]decane-7-carboxylate

Name: tert-Butyl 2-hydroxy-7-azaspiro[3.6]decane-7-carboxylate
Brand: ChemScene
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CAS No. 1445951-30-3
Cat. No. CS-0036037
Purity≥95%
MDL No.MFCD25509380

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl 2-hydroxy-7-azaspiro[3.6]decane-7-carboxylate|CS-0036037

Structure of 1445951-30-3

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General Information

CAS No. 1445951-30-3
Cat. No. CS-0036037
Purity ≥95%
MDL No. MFCD25509380
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₅NO₃
Molecular Weight 255.35
Synonym(s) Tert-Butyl 2-Hydroxy-7-Azaspiro[3.6]Decane-7-Carboxylate(WX101493)
SMILES CC(C)(C)OC(=O)N1CCCC2(CC1)CC(C2)O

Description

tert-Butyl 2-hydroxy-7-azaspiro[3.6]decane-7-carboxylate is a sterically shielded spirocyclic scaffold featuring a hydroxyl group and a bench-stable tert-butyl ester. This configuration enables direct functionalization at the nitrogen center while maintaining structural integrity under standard reaction conditions. The molecule serves as a key intermediate in the synthesis of complex nitrogen-containing polycycles.

Application

tert-Butyl 2-hydroxy-7-azaspiro[3.6]decane-7-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry applications, offering a rigid, three-dimensional core with defined stereochemistry. The hydroxyl group enables derivatization via esterification or ether formation, while the tert-butyl carbamate facilitates selective deprotection under mild acidic conditions. Its stability and compatibility with standard coupling reactions make it valuable for constructing complex heterocycles and drug-like molecules in iterative synthesis workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 49.77
LogP 2.5485
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Skeleton Aliphatic heterocycle compounds Other aliphatic heterocycles compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Key Words

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tert-Butyl 2-hydroxy-7-azaspiro[3.6]decane-7-carboxylate

CAS No. 1445951-30-3

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