4-Bromo-2,2-difluoro-1,3-benzodioxole

Name: 4-Bromo-2,2-difluoro-1,3-benzodioxole
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 144584-66-7
Cat. No. CS-W001180
Purity≥97%
MDL No.MFCD01631385

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2,2-difluoro-1,3-benzodioxole|CS-W001180

Structure of 144584-66-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 144584-66-7
Cat. No. CS-W001180
Purity ≥97%
MDL No. MFCD01631385
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃BrF₂O₂
Molecular Weight 237.00
Synonym(s) 1,3-Benzodioxol-4-bromo,2,2-difluoro
SMILES Brc1cccc2c1OC(O2)(F)F

Description

4-Bromo-2,2-difluoro-1,3-benzodioxole features a brominated aromatic core with two fluorine atoms at the 2-position, imparting enhanced electron-withdrawing character and metabolic stability. This trifluorinated benzodioxole scaffold serves as a robust building block in medicinal chemistry, enabling efficient coupling reactions under standard conditions while maintaining bench-stable handling properties.

Application

4-Bromo-2,2-difluoro-1,3-benzodioxole serves as a versatile building block in medicinal chemistry, enabling the introduction of both bromo and difluoromethylene motifs into complex scaffolds. Its stability under standard synthetic conditions facilitates palladium-catalyzed cross-coupling reactions, while the ortho-difluoro substitution enhances metabolic stability and modulates electronic properties. The molecule functions effectively in the synthesis of fluorinated heterocycles and bioactive compounds requiring halogenated aromatic cores.

Synthesis

Route1
- In-stock
  
  1583-59-1
- ~71%
- In-stock
  
  144584-66-7
References
- Schlosser, Manfred; Gorecka, Joanna; Castagnetti, Eva European Journal of Organic Chemistry, 2003 , # 3 p. 452 - 462

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07,GHS09
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H227-H315-H319-H335-H401-H411
Precautionary Statements : P210-P261-P264-P271-P273-P280-P302+P352-P305+P351+P338-P362-P370+P378-P391-P403+P233-P403+P235-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 18.46
LogP 2.7706
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Key Words

4-Bromo-2,2-difluoro-1,3-benzodioxole sigma4-Bromo-2,2-difluoro-1,3-benzodioxole manufacturer4-Bromo-2,2-difluoro-1,3-benzodioxole price4-Bromo-2,2-difluoro-1,3-benzodioxole structure4-Bromo-2,2-difluoro-1,3-benzodioxole SDSbuy 4-Bromo-2,2-difluoro-1,3-benzodioxole4-Bromo-2,2-difluoro-1,3-benzodioxole supplier4-Bromo-2,2-difluoro-1,3-benzodioxole uses4-Bromo-2,2-difluoro-1,3-benzodioxole molecular weightprice of 4-Bromo-2,2-difluoro-1,3-benzodioxole4-Bromo-2,2-difluoro-1,3-benzodioxole chemical name formula of 4-Bromo-2,2-difluoro-1,3-benzodioxole

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Bromo-2,2-difluoro-1,3-benzodioxole

CAS No. 144584-66-7

Recommended Products