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CS-W001157 4
Total: USD 88.00

4-Methylenepiperidine hydrochloride

  • CAS No. 144230-50-2

  • Cat. No. CS-D0508
  • Purity≥98%
  • MDL No.MFCD17977038

*For research and further manufacturing use only, not for direct human use.

4-Methylenepiperidine hydrochloride|CS-D0508

Structure of 144230-50-2

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General Information

  • CAS No. 144230-50-2
  • Cat. No. CS-D0508
  • Purity ≥98%
  • MDL No. MFCD17977038
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClN
  • Molecular Weight 133.62
  • Synonym(s) Piperidine, 4-methylene-, hydrochloride
  • SMILES C=C1CCNCC1.Cl

Description

4-Methylenepiperidine hydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring a reactive exocyclic methylene group. This structural motif enables direct conjugate addition reactions and facilitates efficient coupling in synthetic routes to bioactive compounds. The hydrochloride salt enhances solubility in aqueous and polar organic media, streamlining handling in medicinal chemistry workflows.

Application

4-Methylenepiperidine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles. The pendant methylene group facilitates Michael additions and ring-opening reactions, while the protonated piperidine core ensures excellent solubility and ease of purification. Its bench-stable form simplifies handling in multi-step syntheses, making it well-suited for late-stage functionalization and scaffold diversification in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.3478
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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