Lot numbers can be found on the outside label of a product:
tert-Butyl 4-formylphenylcarbamate
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CAS No. 144072-30-0
- Cat. No. CS-0042029
- Purity≥97%
- MDL No.MFCD06245541
*For research and further manufacturing use only, not for direct human use.
Structure of 144072-30-0
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General Information
- CAS No. 144072-30-0
- Cat. No. CS-0042029
- Purity ≥97%
- MDL No. MFCD06245541
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₁₅NO₃
- Molecular Weight 221.25
- Synonym(s) Tert-butyl (4-formylphenyl)carbamate
- SMILES CC(C)(C)OC(=O)NC1=CC=C(C=O)C=C1
Description
tert-Butyl 4-formylphenylcarbamate features a para-formyl group on a phenyl ring, enabling direct functionalization in synthetic sequences. The tert-butyl carbamate moiety provides stable protection for amine intermediates, facilitating orthogonal reactivity in complex molecule assembly. This compound integrates cleanly into multi-step syntheses requiring selective transformations and mild deprotection conditions.
Application
tert-Butyl 4-formylphenylcarbamate serves as a versatile building block in medicinal chemistry, enabling direct introduction of both formyl and carbamate functionalities. The formyl group facilitates nucleophilic additions and reductive amination protocols, while the tert-butyl carbamate offers orthogonal protection for amines. Its bench stability and compatibility with standard coupling and reduction conditions make it ideal for modular synthesis of substituted benzene derivatives and heterocyclic scaffolds.
Synthesis
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Route1
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In-stock
144072-29-7 - ~94%
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In-stock
144072-30-0
References
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Schadendorf, Torsten; Hoppmann, Christian; Rueck-Braun, Karola Tetrahedron Letters, 2007 , vol. 48, # 51 p. 9044 - 9047
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Route2
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In-stock
143090-18-0 - ~95%
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In-stock
144072-30-0
References
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Ko, Sung-Bo; Oh, Eu-Gene; Kim, Eon-Kyeom; Kim, Won-Yeob; Choi, Dennis W.; Dugan, Laura L.; Koh, Jae-Young; Won, Moo-Ho; Wie, Myung-Bok Patent: US2003/220337 A1, 2003 ;
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Route3
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917-61-3 -
In-stock
104-88-1 -
75-65-0
- ~75%
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In-stock
144072-30-0
References
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Vinogradova, Ekaterina V.; Park, Nathaniel H.; Fors, Brett P.; Buchwald, Stephen L. Organic Letters, 2013 , vol. 15, # 6 p. 1394 - 1397
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07,GHS08
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Signal Word : Danger
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H334-H412
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Precautionary Statements : P261-P264-P270-P273-P284-P304+P340-P330-P501
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Quality Control
Computational Chemistry Data
- TPSA 55.4
- LogP 2.8461
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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