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Structure of 14401-72-0
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1-(3,5-Dichlorophenyl)ethanone features a sterically hindered aryl ketone core with two electron-withdrawing chlorine substituents at the meta and para positions. This configuration enhances electrophilicity at the carbonyl carbon while providing robust stability under standard bench conditions. The compound serves as a key building block in synthetic routes to pharmaceutical intermediates and functionalized aromatic systems.
1-(3,5-Dichlorophenyl)ethanone serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. Its aryl ketone functionality enables reliable enolization, nucleophilic addition, and coupling reactions under standard conditions. The electron-withdrawing dichlorophenyl group enhances electrophilicity at the carbonyl carbon while providing metabolic stability. Bench-stable and amenable to purification via recrystallization, it functions effectively in Friedel-Crafts acylations, multicomponent condensations, and as a precursor to chiral intermediates through asymmetric reduction.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: