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CS-W001157 4
Total: USD 88.00

(S)-2-Methyl-3-phenylpropanoic acid

  • CAS No. 14367-54-5

  • Cat. No. CS-0644493
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-2-Methyl-3-phenylpropanoic acid|CS-0644493

Structure of 14367-54-5

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General Information

  • CAS No. 14367-54-5
  • Cat. No. CS-0644493
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₂
  • Molecular Weight 164.20
  • Synonym(s) None
  • SMILES OC([C@@H](C)CC1=CC=CC=C1)=O

Description

(S)-2-Methyl-3-phenylpropanoic acid is a chiral benzylic carboxylic acid featuring a stereogenic center at the 2-position. This configuration imparts distinct reactivity and recognition properties in asymmetric synthesis, enabling selective incorporation into biologically relevant scaffolds. The molecule’s phenyl group enhances π-stacking potential, while its aliphatic side chain provides tunable hydrophobicity. This compound serves as a key building block for pharmaceutical intermediates and functional materials requiring defined stereochemistry.

Application

(S)-2-Methyl-3-phenylpropanoic acid serves as a chiral building block for pharmaceutical intermediates and bioactive molecule synthesis. Its well-defined stereochemistry and stability enable reliable incorporation into diverse synthetic sequences, including amide coupling and derivatization reactions. The aryl-substituted side chain facilitates π–π interactions in target binding domains, while the α-methyl group enhances metabolic resistance—making it valuable for medicinal chemistry optimization and scale-up applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.9498
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   3

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