Exatecan Intermediate 6

Name: Exatecan Intermediate 6
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 143655-58-7
Cat. No. CS-0113881
Purity≥98%
MDL No.MFCD31716093

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 143655-58-7
Cat. No. CS-0113881
Purity ≥98%
MDL No. MFCD31716093
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₄FNO₂
Molecular Weight 235.26
Synonym(s) None
SMILES CC(NC(C=C(F)C(C)=C1CCC2)=C1C2=O)=O

Description

Exatecan Intermediate 6 features a strategically positioned lactam moiety and electron-deficient aromatic system, enabling direct integration into complex natural product syntheses. This bench-stable derivative supports efficient coupling reactions under standard conditions, offering reliable access to advanced exatecan analogs in medicinal chemistry workflows.

Application

Exatecan Intermediate 6 serves as a key building block in the synthesis of exatecan-based anticancer agents, featuring a substituted indolocarbazole core with defined regiochemistry. It functions as a versatile scaffold for late-stage functionalization, enabling efficient coupling reactions under standard conditions. The intermediate exhibits excellent bench stability and facilitates straightforward purification, supporting scalable synthesis workflows in medicinal chemistry and process development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 46.17
LogP 2.61152
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Amide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

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Exatecan Intermediate 6

CAS No. 143655-58-7

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