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CS-W001157 4
Total: USD 88.00

2-Bromo-1,4-dichlorobenzene

  • CAS No. 1435-50-3

  • Cat. No. CS-W021588
  • Purity≥98%
  • MDL No.MFCD00018505

*For research and further manufacturing use only, not for direct human use.

2-Bromo-1,4-dichlorobenzene|CS-W021588

Structure of 1435-50-3

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General Information

  • CAS No. 1435-50-3
  • Cat. No. CS-W021588
  • Purity ≥98%
  • MDL No. MFCD00018505
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrCl₂
  • Molecular Weight 225.90
  • Synonym(s) 1-BROMO-2,5-DICHLOROBENZENE
  • SMILES ClC1=CC=C(Cl)C(Br)=C1

Description

2-Bromo-1,4-dichlorobenzene is a halogenated aromatic compound featuring complementary reactive sites for cross-coupling and functionalization. The bromo group enables palladium-catalyzed coupling reactions, while the para-dichloro substitution provides structural rigidity and enhanced stability. This scaffold serves as a key intermediate in synthesizing complex polycyclic architectures and bioactive molecules.

Application

2-Bromo-1,4-dichlorobenzene serves as a versatile building block in cross-coupling chemistry, enabling palladium-catalyzed reactions such as Suzuki-Miyaura and Stille couplings due to its stable halogen functionality. The ortho-bromine facilitates selective transformation while the para-dichloro substitution provides electronic tuning and enhanced bench stability. Its predictable reactivity and ease of purification make it a practical choice for constructing complex aryl scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      95-82-9
    • ~92%
    • In-stock
      2-Bromo-1,4-dichlorobenzene|CS-W021588
      1435-50-3

    References

    • Sturala, Jiri; Cibulka, Radek European Journal of Organic Chemistry, 2012 , # 36 p. 7066 - 7074
  • Route2

    References

    • Banerjee, Amalendu; Banerjee, Gopal Chandra; Dutt, Sachchidananda; Banerjee, Santa (Mrs.); Samaddar, Haraprasad Journal of the Indian Chemical Society, 1980 , vol. 57, # 6 p. 640 - 642
  • Route3

    References

    • Green Chemistry, , vol. 14, # 9 p. 2380 - 2383

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.7559
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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